Abstract
A rapid, simple, cost-effective, accurate and precise direct titrmetric method for the determination of isoniazid (INH) in pharmaceutical preparations has been developed and validated. The method is based on the titration of INH with 0.02 M acetous perchloric acid in glacial acetic acid using crystal violet as indicator. The method is applicable over the range of 1.5–15.0 mg INH. The validation of the method yielded good results that included precision (RSD < 3% for intra- and inter-day precision), and accuracy (relative error ≤2.6%). It was also found that the excipients in the commercial tablet preparation did not interfere with the assay and the results were comparable with the official method.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
