Abstract
A simple and efficient methodology has been developed for the one-pot preparation of α-methylene-γ-butyrolactones by free-radical induced Barbier-type reaction of methyl 2-(bromomethyl)acrylate and aldehydes followed by in situ lactonization. The radical initiator titanocene(III) chloride (Cp 2TiCl) was easily generated in situ from commercially available Cp 2TiCl 2 and activated zinc dust in THF. Ketones remained unaffected under the reaction conditions.
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