Abstract

SummaryWhereas, in our series, serum manganese values in patients with congenital, infectious, degenerative, or neoplastic disease were below 1.9 μg/100 ml of serum, serum manganese was elevated above 2.0 μg following acute myocardial infarction in every instance. Massive pulmonary infarction, which also may be accompanied by high serum manganese levels, can be differentiated from myocardial infarction by additional information supplied by serum aluminum values, which are elevated following pulmonary injury but not following myocardial damage. In patients with myocardial infarction, height of the serum manganese level provides an index to extent and severity of cardiac damage as estimated on the basis of SGOT level and the ECG. Although a close correlation exists between SGOT and serum manganese values, our data indicate that serum manganese concentrations are less likely to yield false positive indications of myocardial damage.

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