Abstract
The morphological and functional capacity of cells maintained in organ culture may offer a system for cultivating viruses which closely simulates conditions in the intact host. Several attempts to propagate the hepatitis B virus in organ cultures have recently been reported. Hepatitis B antigen may be produced in suitable preparations of human embryo liver in organ culture. A progressive rise in the titre of antigen, as measured by several techniques, has been demonstrated with a limited number of sera; and one successful passage of harvested material from cultures on day 8 has been accomplished with two specimens. A most important and urgent need is the adaptation of the agent passaged in organ culture to growth in readily available cell cultures, because of the difficulty in obtaining suitable human fetal liver.
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