Abstract
BackgroundThe aim of this study was to explore the feasibility and reproducibility of a time-efficient coronary vessel wall measurement approach using an improved motion-sensitized driven equilibrium (iMSDE) pulse sequence.MethodologyIn this study, the iMSDE pulse sequence was first optimized and then applied on a group of healthy volunteers (N = 10) to evaluate its feasibility of vessel wall visualization. The same technique was also applied on a separate group of volunteers (N = 19) for a reproducibility study by scanning the same subject in two separate sessions. The iMSDE sequence was found to provide good coronary vessel wall delineation. It was also found to provide reproducible coronary vessel wall diameter and thickness measurements in both proximal and middle segments of the right coronary artery.ConclusionThe feasibility and reproducibility of iMSDE based coronary vessel wall imaging were demonstrated for the first time, paving the way for further testing in a clinical environment for fast and accurate coronary artery disease detection.
Highlights
Coronary artery disease (CAD) remains the number one cause of death in the Western world [1] and over half of all patients with sudden cardiac death do not experience typical symptoms such as chest pain prior to the event [2,3]
The feasibility and reproducibility of improved motion-sensitized driven equilibrium (iMSDE) based coronary vessel wall imaging were demonstrated for the first time, paving the way for further testing in a clinical environment for fast and accurate coronary artery disease detection
Study design In the first part of the study, the iMSDE sequence was tested for feasibility and optimized to acquire coronary vessel wall (CVW) in a time efficient manner
Summary
Coronary artery disease (CAD) remains the number one cause of death in the Western world [1] and over half of all patients with sudden cardiac death do not experience typical symptoms such as chest pain prior to the event [2,3]. With excellent soft tissue contrast, MRI is capable of detecting luminal narrowing [9], and positive remodeling [10] of the coronary vessel wall (CVW) [11]. The latter phenomenon has been traditionally regarded as a pivotal sign of clinically relevant future coronary artery disease [12], and might influence individual treatment decisions. The aim of this study was to explore the feasibility and reproducibility of a time-efficient coronary vessel wall measurement approach using an improved motion-sensitized driven equilibrium (iMSDE) pulse sequence
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