Abstract
The hypothalamic-pituitary-thyroid axis has been studied in genetically obese rats, in lean littermates and littermates which became obese following hypothalamic injury (lesioned). After exposure to cold (3°C), the half-life for thyroid radioactivity in the genetically obese rats decreased from 4.73 d to 2.44 d; the plasma FFA showed no elevation and body temperature fell significantly. Lean littermates had a decrease in thyroidal half-life from 1.73 d to 0.92 d, showed the expected rise in FFA but had no fall in body temperature. Lesioned rats had no change in release of thyroid iodine but increased their FFA, and showed no significant change in body temperature. In rats maintained at 18°C the weight of the pituitary was significantly reduced in the genetic obese rats, but the concentration of thyrotropin (TSH) was similar in lean and genetically obese rats. Plasma TSH in fatties rose slightly after feeding a diet supplemented with propylthiouracil. Plasma TSH did not rise when genetic obese rats were fe...
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