Abstract
The influence of 17β-estradiol (E2) injections on plasma thyroid hormonesand growth hormone (GH) and on pituitary thyrotropin-releasing hormone(TRH) binding was studied in 19-day-old chick embryos. The E2 injectionraised plasma levels of thyroxine (T4) and triiodothyronine (T3) withoutincreases in the peripheral 5'-monodeiodination (5'-D) and the T3 to T4 ratio.The injection had no significant effect on plasma GH concentrations. PituitaryTRH binding was not affected by E2-treatment, suggesting that as contrastedwith findings in mammals, changes in pituitary TRH receptor levels may not beresponsible for the thyrotropic action of E2 in the chick embryo.
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