Abstract
The increase in serum thyroid-stimulating-hormone (T.S.H.) levels recorded twenty and sixty minutes after the intravenous administration of 200 μg. of synthetic thyrotrophin-releasing hormone (T.R.H.) can be used as a test of thyroid function. The normal range of serum-T.S.H. (95% confidence limits) at twenty minutes is 3·5-15·6 μU per ml. for men and 6·5-20·5 μU per ml. for women, and at sixty minutes 2·0-11·5 μU per ml. for men and 4·0-15·6 μU per ml. for women. Women show a significantly greater response to T.R.H. at both the times. Patients with hypothyroidism due to primary thyroid disease exhibited an exaggerated and prolonged T.S.H. response to T.R.H. Patients with hyperthyroidism did not respond at all. It is suggested that, in the absence of pituitary or hypothalamic disease, the response of serum T.S.H. to T.R.H. provides a simple, safe, sensitive, and reliable test of thyroid function.
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