Abstract
This study aimed to evaluate the levels of thyroid hormones and lactate dehydrogenase (LDH) isoenzymes in obese and/or diabetic patients. Forty male subjects categorized into four equal groups; group 1: Non obese control subjects, group 2: Subjects suffering from type 2 diabetes mellitus (T2DM), group 3: Obese subjects (BMI ≥ 30 kg/m2) and group 4: Subjects thatwere obese and had type 2 diabetes mellitus (T2DM). Liver, kidney, lipid, thyroid hormones, total LDH and LDH isoenzymes levels were determined. There was a significant increase of TSH level (p<0.001) in diabetic group as compared with control group and a highly significant increase of TSH was obtained in obese and obese diabetic groups versus control and diabetic patients. LDH 2 was also highly significantly decreased in obese and obese diabetic groups versus diabetic patients. Percentage of LDH 4 was significantly decreased in both diabetic and obese groups and not significantly changed in obese diabetic patients as compared with the control group. LDH 5 percentage showed very highly significant decrease in diabetic, obese and highly significant decrease in obese diabetic groups when compared with control subjects while it was not significantly changed in obese and obese diabetic groups as compared with diabetic patients. LDH isozymes can be used as valuable diagnostic markers for metabolic syndrome. This may help to explore the metabolic changes associated with obesity and diabetes complication and following up the complication of these abnormalities.
Highlights
Diabetes mellitus, often referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produceAfrican Health Sciences body weight or body mass index
Background: This study aimed to evaluate the levels of thyroid hormones and lactate dehydrogenase (LDH) isoenzymes in obese and/or diabetic patients
Subjects and methods: Forty male subjects categorized into four equal groups; group 1: Non obese control subjects, group 2: Subjects suffering from type 2 diabetes mellitus (T2DM), group 3: Obese subjects (BMI ≥ 30 kg/m2) and group 4: Subjects thatwere obese and had type 2 diabetes mellitus (T2DM)
Summary
Often referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produceAfrican Health Sciences body weight or body mass index Patients suffering from diabetes mellitus either type 1 (IDDM) or type 2 (NIDDM) are at high risk for diseases whose etiology is related to various factors such as metabolic abnormalities and its enzymes such as lactate Dehydrogenase (LDH)[4]. Some of the organs relatively rich in LDH are the heart, kidney, liver, and muscles[3] Because this enzyme is composed of five different isoenzymes, analysis of the different LDH isoenzyme levels in the blood can help in the diagnosis of some diseases. This study aimed to evaluate the levels of thyroid hormones and lactate dehydrogenase (LDH) isoenzymes in obese and/or diabetic patients. Conclusion: LDH isozymes can be used as valuable diagnostic markers for metabolic syndrome This may help to explore the metabolic changes associated with obesity and diabetes complication and following up the complication of these abnormalities.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
