Abstract
Due to limited available information of the correlation between T3 and T4 on uterine cancer. This study focused on the following: Possibility of T3 and T4 as a marker of uterine cancer by studying the relationship between T3 and T4 and uterine cancer through a hormonal parameters. The study included collection of samples attending the Hospitals in Mosul, divided to two groups (40 healthy women and 35 women diagnosed with uterine cancer only). Each patient was evaluated clinically and by a biochemical laboratory tests, which include estrogen, progesterone, T3, T4, adiponectin and BMI in serum. The results showed that T3 and T4 may increases the incidence of uterine cancer especially after menopause because its increase significantly BMI and estrogen and decreased adiponectin lead to disorder in hormonal imbalance in women body. Novel of this research showed that thyroid hormones are a new risk factor for uterine cancer especially after menopause. Accordingly, women should pay attention for the level of thyroid hormones during menopausal age to reduce the risk of uterine cancer.
Highlights
The concept that hormones can cause increase the incidence of human cancer is mainly seen in for the four hormone-related cancers which are numerically the most important, namely, breast, prostate, uterus and ovary
This study focused on the following: Possibility of T3 and T4 as a marker of uterine cancer by studying the relationship between T3 and T4 and uterine cancer through a hormonal parameters
The results showed that T3 and T4 may increases the incidence of uterine cancer especially after menopause because its increase significantly BMI and estrogen and decreased adiponectin lead to disorder in hormonal imbalance in women body
Summary
The concept that hormones can cause increase the incidence of human cancer is mainly seen in for the four hormone-related cancers which are numerically the most important, namely, breast, prostate, uterus and ovary. Even for these sites, large gaps remain in our knowledge of the responsible hormones and the conditions which create the optimal opportunity for carcinogenesis (Schottenfeld and Fraumeni, 2006). Thyroid function may vary in obese women in association with body weight and fat mass (Reinehr, 2010), obesity can exacerbate the age-related decline in physical function and lead to frailty (Villareal et al, 2011). Aim of the study is the possibility T3 and T4 as a marker of uterine cancer by studying the relationship between T3 and T4 and uterine cancer through a hormonal parameters and study the effect according to the age
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