Abstract
The aim of this study was to compare thyroid function in preterm infants born to women with placental insufficiency (n= 15) and those born to women without placental insufficiency (n= 13). Gestational ages ranged between 28 and 33 weeks. Concentrations of free thyroxine (FT4), thyrotropin (TSH), triiodothyronine (T3) and reverse T3 (rT3) were measured by radioimmmunoassays in cord blood and on d 1,3,5,7,14 and 21. Infants born to the women with placental insufficiency had significantly lower mean FT4 (p = 0:001), TSH (p= 0:002) and rT3 values (p= 0:025) in cord blood, and higher rT3 values on d 5 (p = 0:019) and d 7 (p= 0:025). The following conclusions were reached: (i) preterm infants born to preeclamptic women with placental insufficiency have intact hypothalamic‐pituitary‐thyroid axes; (ii) compared to preterm infants born to healthy women, preterm infants born to pre‐eclamptic women with placental insufficiency have lower FT4 and TSH concentrations before birth and (iii) elevated rT3 concentrations after birth, suggesting a temporarily impaired hepatic type 1 deiodination process.
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