Abstract
Thymus carnosus is a thyme species rich in bioactive compounds with potential medicinal properties, but the effect of its extract are poorly studied. This work aims to compare the effect of aqueous (decoction) and hydroethanolic (HE) extracts from T. carnosus aerial parts, concerning anti-proliferative activity and underlying mechanisms.Caco-2 and HepG2 cells exposure to extracts induced dose- and time-dependent reduction in cell viability. Decoction showed very low toxicity (IC50 > 500 µg/mL (both cell lines) comparing to HE (IC50 ∼ 30 (Caco-2) and ∼120 (HepG2) µg/mL). Dose-dependent cell cycle arrest was observed in Caco-2 cells exposed to both extracts. At IC50 concentrations, HE extracts only slightly increase Annexin/PI double staining, while decoction extracts significantly increased Annexin/PI fluorescence which results in a dose-dependent large increase of cells in late apoptosis.In conclusion, Thymus carnosus anti-proliferative activity against Caco-2 cells highlights the potential of this plant, and its extracts, as functional food/ingredient with nutraceutical and pharmacological value.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
