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Abstract
Umbilical vein grafts were placed in the carotid arteries of sheep and removed after 10 or 90 days for determination of in vitro production of 6-keto-PGF 1α and thromboxane B 2 (TxB 2) in the anastomoses and in the middle of the grafts. At both intervals the grafts produced much more TxB 2 than carotid arteries, but no significant difference in production of 6-keto-PGF 1α was found between grafts and carotid arteries. The strongly decreased 6-keto-PGF 1α/TxB 2 ratio indicates a low resistance to platelet adhesion and aggregation, which may be a contributory cause of the thrombogenicity of vascular grafts and may possibly be involved in the pathogenesis of neotintimal fibrous hyperplasia.
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