Abstract
Background: Previous studies in patients with cardiovascular disease have reported increased thrombotic and decreased fibrinolytic potentials, heightening the risk of thrombosis. Recent research has shown that many acute cardiac events occur during or following heavy muscular exertion, predominantly due to an occlusive thrombus. Although resistance training is widely recommended for persons with and without chronic disease, the acute coagulative responses to this form of exercise have not been evaluated in patients with coronary artery disease (CAD). The present study was designed to evaluate changes in thrombotic and fibrinolytic potentials following an acute bout of strength training in patients with CAD. METHOD: Ten men (mean ± SD age = 60.2 ± 9.1 years) with documented CAD, who had not previously engaged in a strength training regimen, were recruited from our outpatient (phase II and III) cardiac rehabilitation programs to participate. Each subject completed one set of 10 repetitions to volitional fatigue on eight separate resistance training devices. Blood samples (5cc) were drawn pre-exercise, postexercise, and 1-hour post-exercise in a seated position. All values were corrected for plasma volume changes. Alterations in tPA activity and antigen, PAI-1 activity, and Factor VIII antigen were analyzed using a one-way repeated ANOVA. RESULT: Mean ± SD thrombotic and fibrinolytic responses over time are shown in the table. Although Factor VIII antigen and tPA activity remained unchanged from pre-exercise values, tPA antigen and PAI-1 activity increased and decreased, respectively, in the immediate post-exercise recovery period. Moreover, the latter reduction persisted at 1-hour post-exercise. CONCLUSION: An acute bout of resistance training improves fibrinolytic potential in patients with CAD, without elevating thrombotic potential. These data support the safety of resistance training in this population when contemporary prescriptive guidelines are employed.Table: No Caption Available
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