Abstract
The three-component coupling of aldehydes, amines, and alkynes by using silica-immobilized CuI catalyst was described. Silica-supported copper catalyst SiO 2 -Py-CuI was prepared from 2-pyridylimine functionalized silica SiO 2 -Py with CuI in acetonitrile (eq. 1). The three-component coupling reactions of aldehydes, amines, and alkynes were carried out in the presence of 5 mol% silica-immobilized CuI catalyst SiO 2 -Py-CuI in acetonitrile at 90 °C to give the corresponding propargylamines in 54-93% yield (eq. 2).
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