Abstract
From the underground parts of Picrorhiza scrophulariiflora, three new caffeoyl glycosides, scrocaffeside A-C (1-3), together with two caffeic acid derivates, 4-O-β-D-glucopyranosyl caffeic acid (4) and 4-methoxycaffeic acid (5) and a phenylethanoid glycoside, scroside D (6), were isolated. Their structures were elucidated on the basis of chemical and spectroscopic evidence and comparisons with literature data of related compounds.
Highlights
The plant Picrorhiza scrophulariiflora (Scrophulariaceae) grows in the high altitude regions in the southeast of Tibet and the northwest of Yunnan in China
Previous phytochemical investigations of this plant led to the isolation of terpenoids [2, 3, 4], iridoid glycosides [5, 6, 7], phenolic glycosides and phenylethanoid glycosides [8,9,10,11,12,13,14]
The three known compounds were identified as 4-O-β-D-glucopyranosyl cafeic acid (4) [15], 4methoxycaffeic acid (5) [16] and scroside D (6) [17] by comparing their physical and spectroscopic data with literature values
Summary
The plant Picrorhiza scrophulariiflora (Scrophulariaceae) grows in the high altitude regions (over 4400 m) in the southeast of Tibet and the northwest of Yunnan in China. Scrocaffeside A (1) was obtained as a white amorphous powder, with [α]D-33.7° (c 0.18, MeOH) and its molecular formula was determined as C30H34O17 by the [M+H]+ quasi-ion peak at m/z 667.1824 The 1H-NMR spectrum of 1 (Table 1) exhibited the characteristic signals of two (trans)-caffeoyl units and two β-glucose unites [anomeric protons at δH 5.50 (1H, d, J = 8.0 Hz) and 4.78 (1H, d, J = 6.8 Hz)].
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