Abstract
Three new acorane sesquiterpenes 1α-isopropyl-4α,8-dimethylspiro[4.5]dec-8-ene-2β,7α-diol ( 1), 1α-isopropyl-4α,8-dimethylspiro[4.5]dec-8-ene-3β,7α-diol ( 2) and 2β-hydroxy-1α-isopropyl-4α,8-dimethylspiro[4.5]dec-8-en-7-one ( 3) were isolated from the culture broth of Trichoderma sp. YMF1.02647. The structures were elucidated using spectroscopic data from 1D, 2D NMR and HRESIMS experiments, and the structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. Antitumor activity experiment showed that compound 2 had inhibitive activity against HL-60, A-549 and MCF-7 cell lines.
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