Abstract
Three new abietane-type diterpenoids, named callicapoic acid M3 (1), callicapoic acid M4 (2) and callicapoic acid M5 (3), were isolated from the Callicarpa macrophylla Vahl. Their structures were established by spectroscopic techniques (IR, UV, MS, 1D and 2D NMR). All the isolated three compounds were evaluated for inhibitory activity on NO production in LPS-activated RAW 264.7 macrophage cells by using MTT assays. Compounds 1, 2 and 3 showed potent inhibitory activity, with inhibition rates of 34.47–40.13%.
Highlights
IntroductionThe genus Callicarpa belongs to the family Verbenaceae, with about 190 species widely distributed
The genus Callicarpa belongs to the family Verbenaceae, with about 190 species widely distributed Thethe genusCallicarpa belongs to the familyVerbenaceae, with Oceanica about 190 species widely throughout tropical and subtropical regions of Asia and and parts of distributed America [1,2].tropical subtropical regions Asia andforOceanica parts of America [1,2]
This paper deals with their structural elucidation and anti-inflammatory activity against RAW 264.7 macrophage cells line determined by means of
Summary
The genus Callicarpa belongs to the family Verbenaceae, with about 190 species widely distributed. Verbenaceae, with Oceanica about 190 species widely throughout tropical and subtropical regions of Asia and and parts of distributed. Callicarpa species are used in Chinese folk medicine for various indications [2]. Callicarpa macrophylla taste,slightly slightlyacrid acrid and with clinical actions medicine. Past phytochemical studies on Callicarpa macrophylla Vahl. Some of the literature diterpenoid compounds in Callicarpa showed potent anti-inflammatory activities [9,10]. Being has reported that diterpenoid compounds in Callicarpa showed potent anti-inflammatory activities interested in finding more biologically active substances from this folk medicine, we further[9,10]. Three new abietane-type diterpenoids 1–3, named callicapoic acids M 3–5 (Figure 1) were isolated from the dried whole herb of Callicarpa macrophylla Vahl. This paper deals with their structural elucidation and anti-inflammatory activity against RAW 264.7 macrophage cells line determined by means of
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