Abstract
DNA-DNA homology measurements showed the presence of three different classes of human adenovirus transforming gene sequences: one specific for highly oncogenic subgroup A (types 12, 18, and 31), the second specific for weakly oncogenic subgroup B (types 3, 7, and 16), and the third specific for transforming subgroup C (types 2, 5, and 6). Adenovirus transforming DNA sequences with molecular weights of 1.6–1.8 × 106 are in common or almost identical among members within the same subgroup. Less than one-third of the transforming DNA sequences are shared among members of different subgroups. All of the DNA fragments containing transforming DNA sequences investigated are located at the end of the molecule.
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