Three-component domino cyclization of novel carbazole and indole fused pyrano[2,3-c]pyridine derivatives

Abstract

A series of novel carbazole and indole fused pyrano[2,3-c]pyridine library were constructed via a three-component domino cyclization of 4-hydroxycarbazole, aromatic aldehydes, and 2-aminoprop-1-ene-1,1,3-tricarbonitrile in anhydrous ethanol using EtONa as a base under microwave irradiation. The 27 examples of the potential chemically and biomedically significant pyrano[2,3-c]pyridine derivatives were first prepared by this simple and efficient method. Moreover, this procedure lowers the number of intermediate technologic stages, reduces the energy consumption, and avoids complicated purification operations.