Abstract
Objectives. Cancer is a very widespread disorder known in world wide since long, but its biochemical features remain unclear. Thyroid carcinomas are the most common endocrine cancer and its frequency continues to escalate. There is evidence that the serum concentration of TSH is an unreliant predictor for the diagnosis of thyroid cancer. The formation of the plasma thiol pool from low and large molecular weight proteins suggests that thiol/disulfide balance is important in cancerous cases. The aim of this study was to investigate an oxidative stress marker (thiol/disulphide homeostasis) and IMA (Ischemia modified albumin), Albumin, CEA (Carcinoembryonic antigen), TSH (Thyroid stimulate hormone), thyroxine (T4), free thyroxine (FT4), triiodothyronine (T3) and free triiodothyronine (FT3) in patients with thyroid cancer and compare the results with healthy controls for the first time in literature. Materials-Methods: A total of 43 participants including 23 patients with thyroid cancer and 20 healthy individuals were included in the study. Serum levels of TSH, T4, FT4, T3 and FT3 have been measured during treatment and follow-up of patients with thyroid carcinoma. Serum levels of TSH, T4, FT4, T3 and FT3, IMA, Albumin, CEA, Native thiol (-SH), disulfide (-S-S) and total thiol (TT) as well as disulphide/native thiol and disulphide/total thiol ratios were compared between the groups. Native thiol, disulfide and total thiol concentrations were measured with a novel automated method (Roche, cobas 501, Mannheim, Germany). Results and conclusion: This paper discusses an oxidative stress marker (thiol/disulphide homeostasis) and tumor markers IMA, Albumin, CEA, TSH, T4, FT4, T3 and FT3 in patients with thyroid cancer and compare the results with healthy controls. Mean age at participant was 41.73 years for thyroid cancer patients (21 females/2 males). A control group of 20 participants was included the study (19 females/1 male, mean age 51.75).
Highlights
Many pathologies and diseases have been linked to oxidative stress [1]
Native thiol (482.45 μmol/L vs 493.98 μmol/L), total thiol (509.13 μmol/L vs 518.15 μmol/L, and disulphide (13.33 μmol/L vs 12.08 μmol/L) levels were lower in thyroid cancer patients when compared to the controls (Table 2)
There were no correlations between serum thiol/disulphide parameters and T3, T4 and TSH hormon in patients with thyroid cancer
Summary
Many pathologies and diseases have been linked to oxidative stress (aging, cancer, cardiovascular disease, respiratory diseases such as asthma and obstructive sleep apnea; diabetes mellitus; rheumatic diseases such as rheumatoid arthritis; urological diseases such as prostate cancer and benign prostatic hyperplasia; neurological diseases such as Parkinson’s and Alzheimer’s) [1]. Thiols are sulphur analogs of alcohols, taking the suffix “-thiol”. Thiol is an organic component consisting sulfid which has a critical role in preventing the formation of any oxidative stress condition in cells [4]. Cells are protected against oxidative damage through thiol and sistein storage found in active parts of proteins such as catalase, superoxyde dismutase,tioredocsin and peroredocsin with thiol glutation at low molecule weight by activating gluation peroxidase and glutation S transferase enzyms. Abnormal thiol/disulfid balance levels are found in patogenesis of various diseases such as diabetes, mellitus, cardiovascular diseases, cancer, rheumatoid arthritis, chronic renal impairment, Parkinson, Alzheimer, multiple sclerosis and liver diseases [7]. Of the low molecule weight thiols, S-glutation (GSH) is searched as a potential biomarker of oxidative stress in some disecises such as renal cancer and diabete, and it is seen at increased level
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