Abstract
AimDetermination the relationship between the epicardial adipose tissue thickness (EATT) and pericoronary adipose tissue thickness (PATT) and the risk of significant coronary artery diseases (CAD) using the coronary artery calcium score (CACS).Materials and methodsThe study group consisted of 80 patients. The risk of significant CAD was estimated based on CACS. Adipose tissue thickness was measured based on multiplanar reformation (MPR), left ventricle short axis and mid-chamber level. EATT in the middle of the length of the right ventricular free wall, PATT around the left anterior descending (LAD), around the left circumflex (LCX) and around the right coronary artery in the posterior interventricular sulcus (RCA).ResultsThe median (IQR) values of CACS and EATT were 12.00 (97.90) and 8.65 (3.90) mm. It was found that in the subgroup CACS = 0 statistically significantly lower than in the subgroup CACS > 0 were mean values EATT and PATT RCA. Based on the regression analysis, it was demonstrated that higher CACS is associated with higher EATT, independent of older age and higher BMI. On the basis the ROC curve analysis, the highest prediction sensitivity of 98.4% was demonstrated for EATT ≥ 16.7 mm as a predictor of high risk of significant CAD and the highest specificity of 61.5% for the criterion EATT ≤ 8.7 mm as a predictor of practically no risk of significant CAD.ConclusionThere is a positive relationship between the risk of a significant CAD estimated based on the coronary artery calcium score and the epicardial adipose tissue thickness.
Highlights
Coronary artery disease (CAD) and its complications comprise one of the main death reasons in general population [1]
Comparing subgroups of patients with different risk of significant CAD, it was demonstrated that the patients with practically no risk of significant CAD are characterized by significantly statistically higher epicardial adipose tissue thickness (EATT) than the patients with minimal risk of significant CAD, patients with mild risk of significant CAD and patients with high risk of significant CAD
Based on the conducted research, one should conclude that in the group of patients qualified for the examination, there is a noticeable positive relationship between the risk of a significant CAD estimated on the basis of the coronary artery calcium score and the epicardial adipose tissue thickness
Summary
Coronary artery disease (CAD) and its complications comprise one of the main death reasons in general population [1]. Coronary heart disease, when considered separately, accounts for about 20% of all deaths, annually [2]. The fundamental diagnostic method of significant coronary artery stenosis is coronary angiography. The relevance of coronary computed tomography angiography (CCTA) as the method of diagnosing of significant coronary artery disease is growing. CCTA is a highly sensitive technique for detecting coronary artery calcium and is being used with increasing frequency for the screening of asymptomatic people to assess those at high risk for developing coronary heart disease (CHD) and cardiac events, as well as for the diagnosis of obstructive CAD in symptomatic patients [3]. In comparison to coronary angiography, cardiac CT has the advantage, that it is a crosssectional technique allowing the evaluation of the vessel lumen and of the vessel wall and the adjacent
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