Abstract
A study of the thiamine diphosphate content and its distribution within the cells of normal and malignant tissues is reported and a comparison is made between the activities of phosphatases decomposing thiamine phosphates. Quantitatively there are wide ranges in the thiamine diphosphate content of various normal tissues. In the tumors examined the amounts are rather small, and are comparable with the lowest normal values. In normal tissues about 30 per cent of the thiamine diphosphate occurs in the mitochondrial fraction and the rest mainly in the supernatant fraction. Only in heart tissue a very low thiamine diphosphate content of the mitochondria, as compared with the supernatant, was found. Also in tumors the main part of thiamine diphosphate was refound in the supernatant fraction. This fact, combined with the low total content of thiamine diphosphate in tumors, means that tumors, as compared with normal tissues, have an extremely low mitochondrial level of thiamine diphosphate. The significance of this phenomenon is discussed. No correlation between thiamine diphosphate content and activity of phosphatases decomposing thiamine phosphates was found.
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