Abstract
Thermophysical properties of polyurethane ureas by thermogravimetry and differential scanning calorimetry were studied. It was shown, that investigated polyurethane ureas are heat-resistant up to 523 K. The structure of polyurethane ureas, containing folate derivative of ferrocene, by wide-angle and small angle X-ray method for different content of folate-derivative of ferrocene was investigated. Wide-angle X-ray diffraction data revealed that the introduction of 0.01 mole of folate derivative of ferrocene to the PUU structure leads to the change of period alternating arrangement of flexible and rigid blocks of PUU, significant degradation of heterogeneous structure, but does not cause changes in amorphous structure of the polymer.
Highlights
Development of new bioactive polymer materials, which can stimulate regeneration processes, for treatment of wounds and burns, due to the needs of modern medicine and remains one of the topical areas of polymer chemistry
Polymer film materials in the research were received by synthesis of diisocyanate prepolymer (DP) based on polyoxypropylene glycol (МW 1000) і 2, 4-; 2, 6-toluene diisocyanate, and the macro chain extending by 4,4'diaminodiphenylmethane (DADPh) and chemically modifing by folate derivative of ferrocene (FKF) in amount of 0.01, 0.03, 0.06 і 0.09 mol, named polyurethane ureas (PUU) (DADPh)-1, PUU (DADPh)-3, PUU (DADPh)-6, PUU (DADPh)-9 respectively [4]
In the result of studying the thermophysical properties of polyurethane ureas of chemically modified by folate ferrocene derivative, it was found that the ferrocene derivatives in the polymer structure do not have a significant effect on their thermophysical properties
Summary
Development of new bioactive polymer materials, which can stimulate regeneration processes, for treatment of wounds and burns, due to the needs of modern medicine and remains one of the topical areas of polymer chemistry. New rapid hemostatic and mild polyurethane-urea foam (PUUF) wound dressing was prepared by the particle leaching method and vacuum freeze-drying method using 4,4-Methylenebis (cyclohexyl isocyanate), 4,4diaminodicyclohexylmethane and poly (ethylene glycol) as raw materials This porous PUUF represents a novel mild wound dressing with excellent water uptake, hemostatic effect and low toxicity, and it can promote wound healing and enhance re-epithelialization [3]. As medical supplies this type noteworthy polyurethane ureas (PUU), chemically modified by folate derivative of ferrocene (FKF), which are capable to stimulate tissue regeneration in the place of usage [4]. It is interesting to study the processes of structure formation of polymer materials, chemically modified by different amounts of folate derivative of ferrocene, and they thermal properties
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