Abstract
One of the trends in the development of modern regeneration medicine is the application of high-intensity laser radiation for deep perforation of biological tissues, stimulating the regeneration of structure and functions of the pathologically changed tissues. In the paper, the possibility to control the location and parameters of the biotissue thermal stimulation zones is studied theoretically and experimentally, depending on the conditions of laser perforation in application to the liver laser-induced regeneration problem. The results of numerical simulation revealed the basic trends in the behaviour of the thermal stimulation zone, which are in good agreement with the experimental data on laser perforation of soft biotissues ex vivo using an optical fibre.
Highlights
One of the trends in the development of regeneration medicine is the application of high-intensity laser radiation for stimulating the recovery of tissue blood supply, structure and functions of vital organs of the human organism
The laser perforation of the cardiac muscle initiates the process of angiogenesis, i.e., the growth of microcapillaries in the zone of the laser impact
The mechanisms of laser revascularisation include the following: i) the development of aseptic inflammation in the perforated region in response to the laser impact with subsequent regeneration and development of microcapillaries; ii) the thermal impact on the tissues surrounding the laser channel, activating different cell elements that are sources of growth factors playing the key role in simulating the angiogenesis process; iii) the formation of multiple microscopic ruptures of the tissue in the channel walls caused by the shockwave impact that establishes a new level of oxygen consumption in the affected volume, improving the blood supply
Summary
One of the trends in the development of regeneration medicine is the application of high-intensity laser radiation for stimulating the recovery of tissue blood supply, structure and functions of vital organs of the human organism. After the laser optical fibre perforation of cirrhotic rat liver (wavelength 1.06 μm), the regeneration of the hepatic tissue with the signs of new microcapillaries and gall ducts formation in the region of laser channels was observed [5,6] These studies were carried out according to the following scheme: the laser perforation of the biological object was carried out with the specified radiation power and exposure time. The present paper is aimed at the study of the possibility to determine and control the location and parameters of the thermal stimulation zone in the tissue caused by laser perforation with an optical fibre at the wavelength 1.56 μm in application to the problem of laser-induced liver regeneration
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