Abstract
BOTH the male and female sex hormones are customarily dissolved in vegetable oil for the purpose of parenteral therapy. These preparations are widely used and are quite satisfactory. There is, however, a significant incidence of a local allergic or irritating action at the site of injection due to the oil. These local reactions are not infrequent,and depend upon the type of vegetable oil used as a vehicle. Those commonly used are derived from sesame, peanut and corn, and the incidence of reactions due to some of these oils may amount to 20 per cent. Sesame oil seems to be the least allergenic. The local induration, itching, bleb formation and swelling of the neighboring tissues are often slight for the first one or two injections, but they become increasingly severe and may cause significant disability and pain for relatively long periods of time. Occasionally a patient will respond to the first injection with a severe reaction.
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