Abstract
Polymer coating for drug delivery system act as command for drug release rate either for instant, sustained or extended prolonged release dosage. This coating layer also is crucial to protect the functional stability of drug that loaded into delivery platform especially the smart delivery systems. Presently, titania nanotube arrays (TNA) platform have been discussed as nanotherapeutic device for drug delivery system especially in localized cancer therapy application. The purpose of this study is to investigate the outcome of chitosan coating on cisplatin-loaded TNA. Chitosan coating on cisplatin-loaded TNA have shown extended cisplatin release activities until day 28 period compared to the uncoated cisplatin-loaded TNA. Burst release was observed within the first 6-h period for both the chitosan uncoated and coated samples. Spike stable cisplatin release from coated TNA sample was observed after day 20, which suggested polymer coating on TNA platform may provide probable an extended-release cisplatin delivery activity. Findings from this work suggest the potential of TNA as nanotherapeutic device for extended cisplatin release platform in localized cancer therapy application.
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