Abstract
Burns commenced publication in 1974. At that time, Stieritz and Holder were working on the development of a murine model for the study of Pseudomonas aeruginosa pathogenesis in burned hosts. The description of this burned mouse model was published the following year [1] and since that time, over 100 primary articles utilizing the model or some permutation thereof, have been published. This model has been used world-wide, from laboratories in Switzerland [2± 10] to Japan [11±15], as well as at the Shriners Hospitals for Children in Cincinnati, where it originated. Topics investigated using the burned mouse model have varied from virulence factors in dierent microorganisms, to measurement and modulation of immune factors, to translocation issues, to numerous sepsis treatments. The particular topics studied have been driven by the state of knowledge and the concerns in burn-infection research at the time of the study. In this article, by examining changes that have occurred in the use of this burned mouse model, we will be reviewing some trends that have occurred in burn infection research over the past 25 years.
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