Abstract
Autoimmune nephritis represents one of the frequent types of kidney pathology. With rates of alcohol consumption being on the rise, it is crucial to study the effects of alcohol abuse on the manifestations of nephropathy. Since the activation of lipid peroxidation plays a significant role in the formation of autoimmune and alcoholic nephropathy, it appears relevant to investigate the potential positive effects of a natural antioxidant, melatonin. The aim of the study was to investigate the effect of melatonin on renal function in chronic alcohol intoxication associated with autoimmune nephritis. Material and methods. The characteristics of changes in electrolyte and water excretory functions of the kidneys in Wistar rats with chronic alcohol intoxication associated with autoimmune nephritis were examined. Experimental chronic alcohol intoxication was obtained by daily intragastric injection through an atraumatic tube of 40% ethanol solution and the administration of isovaleric acid amide solution for 30 days. The model of autoimmune nephritis was obtained via a single subcutaneous injection of an emulsion of complete Freund's adjuvant with an equal volume of a mixture of kidney cortical homogenate at five points. Melatonin was administered intragastrically at a dose of 10 mg/kg for one month. Results. Alcohol intoxication was found to increase the degree of renal dysfunction in autoimmune nephritis. The administration of melatonin as a preventative agent led to a significant reduction in manifestations of nephropathy. Conclusions. Alcohol intoxication may exacerbate the manifestations of autoimmune nephritis. The administration of melatonin in chronic alcohol intoxication associated with autoimmune nephritis leads to the reduction in the severity of pathological changes in the electrolyte-excretory function of the kidneys.
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