Abstract
A 10-year-old boy with the Zollinger-Ellison syndrome is presented. Gastric secretory studies showed a 12 hour basal output of over 2 L.; with Histalog stimulation the acid output was 2 times normal. At laparotomy he was found to have nonbeta islet cell tumor metastases in the liver. No primary tumor was found in the pancreas. An extract of the tumor demonstrated secretory activity, and immunoassay of the patient's blood revealed significant elevation of gastrin. Quantitative studies of the gastric mucosa showed an unusually large parietal cell mass. The boy is well and asymptomatic 2 years following total gastrectomy.
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