Abstract
Experimental studies of the regulation of the dopamine (DA) D3 receptor have utilized techniques causing massive depletions of the DA system. Zitter mutant rats exhibiting a heterogeneous loss of striatal DA innervation were examined for DA transporter (DAT) binding and DA D3 receptor number by autoradiography and compared with Sprague-Dawley rats. A significant loss of DAT binding was observed with the greatest in the lateral caudate-putamen (72% loss) and the least in the nucleus accumbens (45% loss). DA D3 receptors were reduced by > 70% in all regions, even in the nucleus accumbens that exhibited considerably smaller depletions of DAT binding, indicating that loss of D3 receptors may occur prior to massive loss of DA innervation.
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