Abstract
Results We enrolled in the study 80 HIV patients (10 children and 70 adults); M:F = 36:44. All subjects were previously BCG vaccinated, 24 (30%) had positive family contact and 16 (20%) had a history of tuberculosis. 45 (56.2%) patients were in stage C3 (CD4 400). We diagnosed 52 (65%) patients with active or latent TB, out of which 2 cases of pleural effusion, 7 miliary, 22 with pulmonary forms, 8 TB meningitis, 2 lymph nodes TB and one intestinal tuberculosis. Tuberculin skin test (TST) was performed in all patients. Sixteen patients were TST positive: only 2 patients in the group with CD4 400. The QFT test was positive in 27 (33.75%) patients, negative in 44 (55%) and indeterminate in 9 (11.25%). We obtained 14 (31.1%) QFT positive results in patients with CD4 400. In stage C3 (CD4<200) the positive TST tests was significantly lower (4.4%) compared to positive QFT (31.1%).
Highlights
Tuberculosis is the most common opportunistic infection in HIV patients in Romania, but the diagnosis is often difficult because of its many atypical forms.QuantiFERON TB.Gold in Tube (QFT) positive results in group with CD4 = 201-400 and 3 (100%) positive results at patients with CD4>400
QFT positive results in group with CD4 = 201-400 and 3 (100%) positive results at patients with CD4>400
The aim of this study was to evaluate the value of whole interferon-gamma assay, QuantiFERON TB.Gold in Tube (QFT) for the diagnosis of tuberculosis (TB) in HIV patients
Summary
The value of interferon-gamma blood tests for the diagnosis of tuberculosis in HIV patients Background Tuberculosis is the most common opportunistic infection in HIV patients in Romania, but the diagnosis is often difficult because of its many atypical forms. QFT positive results in group with CD4 = 201-400 and 3 (100%) positive results at patients with CD4>400. In stage C3 (CD4
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