Abstract
The effects of prostaglandin F 2α (PGF 2α) on ouabain-induced cardiac arrhythmias were investigated in chloralose-anaesthetized cats. Bilateral vagotomy and atropine intervention were employed to elucidate the involvement of vagal neural influences. PGF 2α (2–16 μg/kg i.v. bolus) predominantly suppressed the ouabain-induced ventricular and supraventricular arrhythmias and less commonly aggravated them in vagi-intact cats. The antiarrhythmic effect of PGF 2α was considerably, but not statistically significantly, decreased while its arrhythmogenic effect was significantly (p < 0.05) increased in atropine-pretreated group. In vagotomised group PGF 2α failed to abolish the arrhythmias but it aggravated them to a degree comparable to that observed in vagi-intact group. It is concluded that the PGF 2α exhibits both antiarrhythmic and arrhythmogenic properties and these are largely due to elicitation of two opposing neural reflexes — one being protective and another being deleterious to ouabain-induced arrhythmias.
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