Abstract
Effects of nootropic or cerebrosprotective drugs on voltage-sensitive Ca 2+ channels (VSCC) in the mammalian brain were evaluated comparatively by depolarization-evoked Ca 2+ channel currents in Xenopus oocytes injected with brain mRNA and by a high K +-stimulated 45Ca uptake into synaptosomes. It was found that several anti-amnesic agents (bifemelane, idebenone and vinpocetine) inhibited these VSCC-related responses with stronger potency than phenytoin and flurazepam. On the inhibiting potency of various compounds. there was a significant but weak correlation between the results from synaptosomes and those from the injected oocytes, since nifedipine, verapamil and diltiazem at 100 μM did not reduce 45Ca influx in synaptosomes but partly inhibited VSCCs in the oocytes. The blockade of neuronal L- and N-type VSCCs may participate in the anti-ischemic/hypoxic actions of nootropic drugs.
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