Abstract
The thermal dilution principle has been applied to the measurement of cardiac output in small laboratory animals. The circuitry is simple, the components are inexpensive and the performance shows stable, linear characteristics. The volume of injectate need be only 0·05 ml at room temperature (25–27° C). Changes in blood temperature of 0·05°C are easily inscribed as a full scale deflection on a commercial d.c. recorder. Numerous successive determinations of cardiac output may be made with minimal changes in blood volume of the animal. Measurements under controlled conditions did not vary by more than 6 per cent.
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