Abstract
The quantitative structure-activity relationships developed by Hansch and his co-workers have been applied to the blood barbiturate levels in fatal cases of poisoning for quinal-barbitone, pentobarbitone, amylobarbitone, butobarbitone and phenobarbitone in order to assess their potential usefulness in the interpretation of the results of toxicological analyses. Histograms and cumulative mortality curves were constructed from literature data and the blood levels of barbiturates causing death in 25%, 50%, 75% and 90% of the cited cases were determined. Regressions of fatal blood levels to n-octanoljwater partition coefficients gave correlation coefficients of between 0.726 and 0.976 showing that Hansch Analysis is applicable to problems in forensic toxicology. The use of Hansch Analysis to predict the likely fatal blood levels of a new drug was examined and the concept supported with reference to one of the barbiturates.
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