Abstract
Summary A controlled trial of the effect of prednisolone on chronic bronchitis was carried out on 39 patients, using a double-blind technique. The period of administration of prednisolone or dummy tablets was one week and results were assessed mainly using two test of ventilatory function (M.B.C. and F.E.V. 1 ). Of 19 patients in the treatment group, 4 were thought to show a true response to the drug with increase in M.B.C. of 7 litres or more and an F.E.V. 1 of more than 150 c.c. One patient in the control group gave an increase of 7 l. in M.B.C. only. Outside the trial proper it was found that 2 of 11 patients who had been on dummy tablets, responded when put on prednisolone, and 4 of 11 patients who had not responded to one week of the drug subsequently improved after more prolonged therapy. It is suggested that a small proportion of patients with chronic bronchitis and emphysema who have not reacted to more conservative treatment will show a response to prednisolone.
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