Abstract
The diagnosis of allergic disease has traditionally relied on clinical history, levels of allergen specific IgE, skin prick tests and for food allergy oral food challenge (OFC). This latter test is considered the gold standard for diagnosis of food allergy and involves the ingestion of gradually increasing amounts of food under medical supervision. During the test, symptoms can range from hives to severe anaphylaxis and this imparts stress in the patient and care provider. The basophil activation test (BAT) and mast cell activation test (MAT) have been proposed as an alternative to OFC but has logistic challenges as the cells need to be evaluated within a few hours of harvest.
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