Abstract
1. 1. Bovine tetanus antitoxin has been used with safety in selected persons known to give severe anaphylactic reactions to horse serum. 2. 2. The only indication for the use of equine tetanus antitoxin occurs in those cases where the person is known to be, or can be demonstrated to be, sensitive to the bovine but not to the equine preparation. Thus far no such cases have been reported. 3. 3. Persons undergoing an allergic study should be tested routinely with equine and bovine sera. This should be done by the scratch method only to avoid as far as possible the sensitizing of the patient to the serum. If the patient is sensitive to both sera, he should be immunized by means of tetanus toxoid, the precautions suggested by Cooke and his associates 5 being carefully observed.
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