Abstract
A chronic sheep model for Doppler umbilical vascular analysis was developed, in which indwelling Doppler probes were used. These were designed with a fixed angle of insonation and implanted directly on the umbilical cord to register umbilical artery velocity waveforms. The fetuses in eight pregnant ewes underwent maternal aortic and umbilical cord constrictions producing serial blood flow reductions. Occlusion of the umbilical cord and maternal aorta caused distinctly different waveforms. Cord occlusion produced an immediate response with an elevated systolic/diastolic ratio and disappearance of diastolic velocity. Maternal aortic occlusion produced a delayed response with drops in both systolic and diastolic velocity; diastolic velocity never reached zero. Although systolic/diastolic ratios are believed to reflect placental resistance, the maintenance of the systolic/diastolic ratio with diminution of systolic velocity suggests declining fetal cardiac output as an additional factor. It is possible to differentiate uteroplacental from umbilicoplacental insufficiency by Doppler methods. With technologic improvements Doppler ultrasonography may allow better analysis of acute stressful conditions during human labor.
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