Abstract
A random urine specimen from a 61-year-old male was collected at an outside clinic for the evaluation of hyponatremia. Although the urine sodium concentration was unremarkable (<20 mmol/L), attempts to measure urine osmolality resulted in a “will not freeze error”; repeat on a separate freezing point depression osmometer yielded the same message. Osmolality is a measure of the number of particles dissolved in a given mass of water. The main contributors to serum and urine osmolality in humans include sodium, chloride, glucose, and urea. Plasma and urine osmolality are typically measured in tandem …
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