Abstract
Ultrastructural studies were undertaken on sections of skeletal muscle from normal pigs and pigs with splayleg from herds with high or low incidence of the disease. Studies were also made of the growth of the muscle from 1 to 7 days after birth. No consistent qualitative differences between the muscles from normal and affected pigs were detected. During the first week of post-natal life, muscle cell cross-sectional areas, intracellular lipid and motor endplate size and complexity increased. Concurrently, the degree of myofibrillar hypoplasia and the area of the extramyofibrillar space (EMS) were reduced. The EMS was occupied by a granular material with a sub-structure of electrondense particles 3 to 7 nm in diameter and was considered to be predominantly glycogen. Evidence is presented that muscle cells were being formed in the early post-natal period. No significant degenerative changes were found in muscle cells from any pig.
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