The tumor ghost on MRI after microwave ablation for hepatocellular carcinoma: A new modality to assess the ablative margin

Abstract

PurposeThe ablated tumor ghost can be visually distinguished on MR images after ablation. This retrospective study aimed to assess the performance of tumor ghost on post-ablation contrast-enhanced MRI with excellular contrast agent gadolinium-DTPA in evaluating the ablative margin of hepatocellular carcinoma (HCC) after microwave ablation (MWA). Method315 HCC lesions less than 5 cm in 287 patients completely treated by MWA were enrolled in the study. The tumor ghost was characterized as a lower signal intensity area than the surrounding tissues of the ablation zone on T1WI imaging. The ablation margin (AM) status was classified into AM0 (＞5mm) and AM1 (＜5mm) according to the minimum distance between the tumor ghost and ablated zone. Inter-observer agreement between two radiologists on the AM assessment was analyzed using the Cohen κ coefficient. Multivariate analysis using Cox proportional hazard model was performed to investigate independent risk factors for LTP. Results175 and 140 tumors were evaluated as AM0 and AM1 through tumor ghost. The inter-observer agreement level between two radiologists for assessment of AM was good (κ coefficient = 0.752, 95 % confidence interval: 0.679–0.825, p < 0.001). The mediate follow-up period was 32.2 months (range 3.0–60.8 months). The incidence of LTP in the AM0 lesions and AM1 lesions was 6.3 % (11/175) and 20.0 % (28/140), respectively. AM status was identified as an independent prognostic factor for LTP (HR 3.057, 95 % CI, 1.445–6.470, p = 0.003). ConclusionsThe assessment of the AM by tumor ghost on post-ablation MRI is an accurate and efficiently method for evaluating the completeness of microwave ablation for hepatocellular carcinoma.