Abstract

目的 观察α-干扰素与无环鸟苷滴眼液治疗单纯疱疹病毒性角膜炎的疗效.方法 39例(47眼)临床诊断为单纯疱疹病毒性角膜炎患者,随机分为常规组及干扰素组.常规组20例用0.1%无环鸟苷滴眼液每日点眼4~6次,并给予常规治疗;干扰素组19例在常规组治疗的基础上,加用α-2b基因工程干扰(IFN-α-2b)滴眼液,每日点眼3~4次,持续时间1~2周.观察治疗前后自觉症状、角膜溃疡愈合、荧光素染色转阴等指标的改变.结果 3例淘汰,有效率干扰素组90.0%,常规组62.5%(P<0.05).结论干扰素与无环鸟苷在治疗单纯疱疹病毒性角膜炎时有协同作用,可提高治愈率。

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