Abstract
The most generally accepted theory of the direct causation of the symptoms of exophthalmic goiter, or Graves' disease, is overactivity of the thyroid gland, and the active portion of its secretion is similarly believed to be a globulin containing iodin, called thyroglobulin. In the attempt to neutralize this secretion or check its production several schemes for serum or allied methods of treatment have been tried. Among these may be mentioned the serum of thyroidectomized dogs drawn after the animal had been operated on and had developed symptoms of athyroidism; the serum of a patient suffering from fully developed myxedema; the serum and the fresh and dried blood and the fresh and dried milk of the thyroidectomized goats, commonly known as Mobius serum; the serum of herbivorous animals which had been fed for varying lengths of time on the thyroid glands of animals of another species, and the serum of animals
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