Abstract
Objective: To investigate the antibacterial effect of baicalin combined with cefoperazone-sulbactam sodium on drug-resistant strains of Pseudomonas aeruginosa. Method: Pseudomonas aeruginosa strains that are sensitive and resistant to cefoperazone-sulbactam sodium were selected to prepare different test bacterial solutions respectively; The test solutions of baicalin and cefoperazone sulbactam sodium were prepared respectively, and different test groups and control groups were set up; The drug sensitivity tests of different concentration gradients of baicalin and cefoperazone sulbactam sodium used alone and in combination were carried out for different sensitive and drug-resistant strains, and the standard strains were used as parallel control. Result: The drug susceptibility test results of the combined use of baicalin and cefoperazone-sulbactam against Pseudomonas aeruginosa drug-resistant strains were compared with the drug susceptibility results of the two used separately, and the difference was statistically significant (P Pseudomonas aeruginosa.
Highlights
Pseudomonas aeruginosa (PAE) is a non-fermenting bacterium, belonging to gram-negative bacilli; It is widely distributed in natural environments such as air, water and soil; It is often colonized or parasitic on gastrointestinal tract, respiratory tract, mucous membrane and skin of healthy people; When human immunity decreases, the bacterium is easy to invade human body and cause hospital infection [1]; it is a common nosocomial opportunistic pathogen, especially in the intensive care unit (ICU) and respiratory ward
The purpose of this study is to find a new method of integrated traditional Chinese and Western medicine in the treatment of drug-resistant PAE, that is, to explore the antibacterial effect of baicalin combined with cefoperazone sulbactam sodium (SCF) on drug-resistant PAE, so as to provide a certain reference basis for clinical treatment
1) Drug susceptibility test results of SCF sensitive strains Baicalin alone, SCF alone, baicalin and the combination of SCF drugs had certain bacteriostatic or bactericidal effects on SCF sensitive strains, and their effect was related and dependent on drug concentration; there was no significant difference in the comparison of OD value of drug sensitivity test results between drug alone and drug combination after cultured at 37 ̊C for 20 hours
Summary
Pseudomonas aeruginosa (PAE) is a non-fermenting bacterium, belonging to gram-negative bacilli; It is widely distributed in natural environments such as air, water and soil; It is often colonized or parasitic on gastrointestinal tract, respiratory tract, mucous membrane and skin of healthy people; When human immunity decreases, the bacterium is easy to invade human body and cause hospital infection [1]; it is a common nosocomial opportunistic pathogen, especially in the intensive care unit (ICU) and respiratory ward. How to control and reduce the occurrence of nosocomial infection and seek new ways and methods to effectively treat PAE resistant strains are the common concern and urgent topic of the majority of medical workers.
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