Abstract
Objective To observe the effects of Dexamethasone and Montelukast on Eotaxin and CCR3 of asthmatic rats.Methods Fourty-eight SD rats were sensitized and challenged by 1％ ovabumin to establish asthmatic model.Results The number of Eotaxin mRNA and Eotaxin protein positive cells as well as the number of CCR3 protein positive cells form group B,C and D were down-regulated significintly,compared to those form group A (P＜0.01).The number of CCR3 protein positive cells in lung tissue and bone marrow form groups B and C,as compared with group D,the difference was significant.Conclusion Dexamethasone probably inhibited the expression of Eotaxin and CCR3; and decreased eosinophil number in the level of bone marrow,Montelukast probably down-regulated them.Montelukast showed apparently synergistic effect with Dexamethasone to inhibit the expression of Eotaxin and CCR3. Key words: Asthma; Eotaxin; CCR3; Dexamethasone; Montelukast
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