Abstract
Fourier transform infrared (FTIR) spectroscopy is a powerful yet relatively inexpensive spectroscopic technique for studying the structure and organization of phospholipid bilayers. This technique yields information about all regions of the phospholipid molecule simultaneously without the necessity of introducing perturbing extrinsic probes. In this review we summarize some recent FTIR spectroscopic studies of the structure and organization of phospholipids in their lamellar liquid-crystalline, gel, and crystalline phases and show that interconversions between these phases can be readily monitored by this technique. We also demonstrate that this technique can yield valuable information about nonlamellar phospholipid phases as well. Finally, we point out that in principle FTIR spectroscopy is capable of yielding fairly high resolution structural and conformational information about phospholipid molecules in multi-molecular aggregates and give several examples of how this potential is beginning to be realized.
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