Abstract
AbstractHydén, H. and Lange, P. W. The steady state and endogenous respiration in neuron and glia. Acta physiol. scand. 1965. 64. 6–14. –The oxygen consumption of individual, surviving nerve cells and glial cells was studied for two hours periods. An extrapolation procedure was worked out which permitted the determination of the oxygen consumption rate in the steady state in vivo and the substrate amount for endogenous respiration. The oxygen consumption rate of the neurons exceeded that of the glia by at least ten times in the steady state. The values obtained were used for calculation of the amount of glucose per nerve cell which was found to be 5 per cent of the dry weight of the cell corresponding to a 70 mM glucose solution. The amount of glucose in glia is 5 to 10 times lower than that of nerve cells. Addition of glucose or β‐hydroxybutyrate to nerve cells having respired without exogenous substrate for two hours highly increased the respiration rate. In neurons with increased RNA synthesis and respiratory enzyme activities, the respiration rate and substrate level were low.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
