THE STATE OF SOME INDICATORS OF HEMOSTASIS IN RELATIVELY HEALTHY PEOPLE AND PATIENTS WITH ISCHEMIC STROKE, TAKING INTO ACCOUNT GENDER DIFFERENCES

Abstract

Goal. To study some indicators of hemostasis in a comparative aspect in patients with ischemic stroke and healthy people, taking into account gender differences.
 Materials and methods. In the course of the study, the hemostasis indices of 160 people were studied. All the examined were divided into two subgroups, the first consisted of 100 donors, 50 men and women each, who did not have acute and chronic diseases. The second group included the study of analogical indicators in 60 people, 30 men and women, with an established diagnosis of acute ischemic cerebral circulation disorder.
 Results. As the results show, differences in hemostasis indicators were found, taking into account gender differences, and disorders in the hemostasis system play an important role in the pathogenesis of ischemic stroke. The obtained results suggest that as a result of the development of endothelial tissue dysfunction, the level of endothelin increased, which led to pronounced vascular spasm and increased procoagulant activity of the blood.
 Conclusion. Based on the conducted research, it was found that in men and women at the time of admission with ischemic stroke, in comparison with the results obtained from donors without established pathology, changes in red blood parameters and rheological properties of blood are observed in the blood. It should be noted that in the group of female patients, changes in the rheological properties of blood were less pronounced than in the group of male patients.